Corneodesmosomal water content in frozen-hydrated porcine skin.

mal thickness of 41.1 μm, whereas sites treated with vehicle alone measured an average of 22.6 μm, indicating a significant difference in epidermal thickness between aTd-treated groups and vehicle controls, Po0.001 (Mann– Whitney test, Figure 1e and f). In summary, we have demonstrated in vivo capabilities of aTds to initiate protect and repair response in non-UVexposed guinea pig skin. By mimicking small DNA molecules, topical aTds were able to induce melanogenesis and epidermal thickening. These findings can have implications in skin photoprotection, cosmetics (non-UV tanning and antiaging), and may guide further research to better understand the cellular responses to UVR without inflicting actual UV damage.